The hosts capitalized on an early defensive error when Joao Gomes played a loose pass across his penalty area in the seventh minute. Lamine Yamal intercepted and curled home his 13th goal of the campaign to give Barcelona an early lead.
Despite missing first-half chances through Nicolas Jackson and others, Aston Villa remained in contention until the second half. Raphinha quickly put the game beyond the visitors with a pair of goals shortly after the interval. The Brazilian forward scored in the 52nd minute via a heavily deflected shot from inside the area, and added a second in the 64th minute by tapping in a cross from Joao Cancelo.
The defeat halted Unai Emery's side's three-match winning run in the competition and marked Aston Villa's joint-heaviest defeat in major European competition.
